Recombinant interleukin-4 enhances the chemiluminescent oxidative burst of murine peritoneal macrophages.
نویسندگان
چکیده
We evaluated the effects of murine recombinant interleukin-4 (rIL-4) on murine peritoneal macrophages. We showed a marked, dose-dependent stimulation of respiratory oxidative burst by IL-4 in peptone-elicited murine peritoneal macrophages. This effect was abolished by a neutralizing monoclonal antibody (mAb) to rIL-4 confirming that the enhanced chemiluminescence was due to IL-4. In contrast, rIL-4 depressed the respiratory oxidative burst of a transformed murine macrophage cell line, J774, in a dose-dependent mAb-reversible manner.
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ورودعنوان ژورنال:
- Journal of leukocyte biology
دوره 49 6 شماره
صفحات -
تاریخ انتشار 1991